Seppälä E, Nissilä M, Isomäki H, Nuotio P, Nykänen E, Laitinen O, Vapaatalo H
Clin Rheumatol. 1985 Sep;4(3):315-20. doi: 10.1007/BF02031615.
The effects of one-day treatment with nine nonsteroidal anti-inflammatory drugs and prednisolone on human synovial fluid concentrations of prostanoids were studied. The doses were calculated so as to be approximately equipotent according to clinical experience and the recommendations of the manufacturers. Most of the drugs used reduced clearly PGE2 and TxB2 levels in synovial fluid, but only a slight diminution in 6-keto-PGF1 alpha values was found. Carprofen, diclofenac, indomethacin, naproxen and tolfenamic acid reduced significantly the synovial fluid PGE2 concentrations. Diclofenac and indomethacin also reduced significantly the synovial TxB2 concentrations.
研究了九种非甾体抗炎药和泼尼松龙一日治疗对人滑液中前列腺素浓度的影响。根据临床经验和制造商的建议计算剂量，使其大致等效。所使用的大多数药物明显降低了滑液中PGE2和TxB2的水平，但仅发现6-酮-PGF1α值略有降低。卡洛芬、双氯芬酸、吲哚美辛、萘普生和托芬那酸显著降低了滑液中PGE2的浓度。双氯芬酸和吲哚美辛也显著降低了滑液中TxB2的浓度。
