类风湿关节炎患者的游离血浆水杨酸浓度。

Unbound plasma salicylate concentration in rheumatoid arthritis patients.

作者信息

Gurwich E L, Raees S M, Skosey J, Niazi S

出版信息

Br J Rheumatol. 1984 Feb;23(1):66-73. doi: 10.1093/rheumatology/23.1.66.

DOI:10.1093/rheumatology/23.1.66

Abstract

This study was designed to investigate the relationship of free plasma salicylate to total plasma salicylate and to determine the clinical utility of monitoring the free plasma salicylate concentration. Analysis of 46 patient samples indicated a close correlation between the free and total plasma concentration and that there is no additional advantage to monitoring the free plasma salicylate concentration. Also this study re-emphasizes the unique pharmacokinetic characteristics of salicylate, whereby the amount of free plasma salicylate increases disproportionately with increased total plasma salicylate concentration.

摘要

本研究旨在调查游离血浆水杨酸与总血浆水杨酸之间的关系，并确定监测游离血浆水杨酸浓度的临床实用性。对46份患者样本的分析表明，游离血浆浓度与总血浆浓度之间密切相关，且监测游离血浆水杨酸浓度并无额外优势。此外，本研究再次强调了水杨酸独特的药代动力学特征，即随着总血浆水杨酸浓度的增加，游离血浆水杨酸的量会不成比例地增加。