类风湿关节炎患者联合治疗期间血清中水杨酸盐和萘普生的浓度。
Serum concentrations of salicylate and naproxen during concurrent therapy in patients with rheumatoid arthritis.
作者信息
Furst D E, Sarkissian E, Blocka K, Cassell S, Dromgoole S, Harris E R, Hirschberg J M, Josephson N, Paulus H E
机构信息
Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City.
出版信息
Arthritis Rheum. 1987 Oct;30(10):1157-61. doi: 10.1002/art.1780301011.
The kinetic interaction between salicylate and naproxen was investigated in 25 rheumatoid arthritis patients. Kinetic interactions were tested in serum after patients had been on each drug regimen for 1 month. Salicylate decreased serum naproxen concentration from 89.5 mg/liter to 65.9 mg/liter (P less than 0.001) and increased serum naproxen clearance by 56%. Naproxen had minimal effect on serum salicylate concentrations.
在25名类风湿性关节炎患者中研究了水杨酸盐与萘普生之间的动力学相互作用。在患者接受每种药物治疗方案1个月后，于血清中测试动力学相互作用。水杨酸盐使血清萘普生浓度从89.5毫克/升降至65.9毫克/升（P<0.001），并使血清萘普生清除率提高了56%。萘普生对血清水杨酸盐浓度的影响极小。
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