Quiros G, Ware J
Eur Surg Res. 1984;16(2):69-76. doi: 10.1159/000128390.
Cardiovascular and thoracic duct lymph (TDL) flow alterations were investigated in non-starved rats, lightly sedated with neuroleptanalgesia, before and after osmolar loading. 0.29-, 1.0- and 2.0-M xylose solutions were infused at the rate of 4 ml X h-1 for 20 min. Neither control animals receiving 0.29-M infusions (iso-osmolar) nor those which received 1- and 2-M infusions showed any detectable changes in cardiac output, heart rate, total peripheral resistance or any organ and tissue flow. On the other hand, TDL flow increased during the hyperosmolar infusions, giving a high degree of correlation with infusion time (r = 0.88 and 0.94, for 1- and 2-M infusions, respectively). These results indicate that hyperosmolar loading has only fluid physiological effects under normotensive conditions.
在未饥饿的大鼠中，用神经安定镇痛法轻度镇静，研究了渗透压负荷前后心血管和胸导管淋巴（TDL）流量的变化。以4 ml·h⁻¹的速率输注0.29 M、1.0 M和2.0 M的木糖溶液，持续20分钟。接受0.29 M输注（等渗）的对照动物以及接受1 M和2 M输注的动物，其心输出量、心率、总外周阻力或任何器官和组织的血流量均未显示出任何可检测到的变化。另一方面，在高渗输注期间TDL流量增加，与输注时间高度相关（1 M和2 M输注的相关系数r分别为0.88和0.94）。这些结果表明，在血压正常的情况下，高渗负荷仅具有液体生理效应。
