Ware J, Quiros G, Norberg K A, Nylander G
Acta Physiol Scand. 1982 Nov;116(3):223-7. doi: 10.1111/j.1748-1716.1982.tb07134.x.
The effects of experimentally induced hyperosmolality has been studied in rats. Renal vascular pedicle ligation was performed on all animals to prevent renal clearance of the infused solute, xylose, and allow accurate ECF space determinations with 51Cr EDTA. Small volume hyperosmolar xylose infusions caused parallel elevation of the osmolality of thoracic duct lymph and arterial plasma. A positive correlation was obtained between lymph osmolality and flow alterations. The maximal osmolality elevation of 22 mosm X kg-1 H2O was associated with an intracellular fluid mobilisation which was equal to 7.1% of the ECF space. The infused and mobilised fluid volumes were distributed unequally between the intra and extra vascular compartments of the ECF.
已经在大鼠中研究了实验性诱导的高渗作用。对所有动物进行肾血管蒂结扎，以防止注入的溶质木糖经肾脏清除，并允许用51Cr乙二胺四乙酸准确测定细胞外液容积。小容量高渗木糖输注导致胸导管淋巴和动脉血浆渗透压平行升高。淋巴渗透压与流量改变之间呈正相关。22 mosm×kg-1 H2O的最大渗透压升高与细胞内液动员有关，细胞内液动员量等于细胞外液容积的7.1%。注入和动员的液体量在细胞外液的血管内和血管外间隙之间分布不均。
