Jaeger P, Portmann L, Jacquet A F, Burckhardt P
Eur Urol. 1984;10(1):53-4. doi: 10.1159/000463512.
Stone formers are often told to select a drinking water with low Ca content. To see whether this measure has a rational biochemical background, 4 Ca hyperabsorbers were asked to drink, first tap water ad libitum, then 2 liters/day of tap water, then 2 liters/day of a low Ca water (A) and finally 2 liters/day of a high Ca water (B). On A, subjects were normocalciuric but hyperoxaluric; whereas on B, they were markedly hypercalciuric but normooxaluric. Therefore, Ca . Ox concentration products were similar on B and A. However, on A as well as on B, Ca . Ox products were much lower than on tap water ad libitum due to the high fluid intake which had thus been imposed. It is concluded that, in the prevention of the recurrence of nephrolithiasis, 'have a high fluid intake' is probably a more relevant advice than 'select a water with a particularly low Ca content'.
结石患者常常被告知要选择钙含量低的饮用水。为了探究这一措施是否有合理的生化背景,研究人员让4名钙吸收过多者先后饮用不同的水:首先是随意饮用自来水,然后是每天饮用2升自来水,接着是每天饮用2升低钙水(A),最后是每天饮用2升高钙水(B)。饮用A水时,受试者的尿钙正常但尿草酸过高;而饮用B水时,他们的尿钙明显过高但尿草酸正常。因此,B水和A水的钙·草酸浓度乘积相似。然而,由于强制增加了液体摄入量,饮用A水和B水时的钙·草酸乘积都远低于随意饮用自来水时的水平。研究得出结论,在预防肾结石复发方面,“大量饮水”可能比“选择钙含量特别低的水”更具相关性。