Ang K K, Landuyt W, Rijnders A, van der Schueren E
Int J Radiat Oncol Biol Phys. 1984 Jan;10(1):95-9. doi: 10.1016/0360-3016(84)90417-6.
The influence of protraction and distribution of irradiation as a function of time on the repopulation kinetics of mouse skin have been evaluated. Twenty fractions have been given either daily for 5 days per week during 4 weeks, or thrice a day to 10 irradiations in 3 days, repeated after a rest period of 19 days, resulting also in an overall time of 4 weeks. The acute skin reaction was scored. It was found that the split course multiple fractions per day (MFD) schedule induced less skin reaction than continuous daily fractionation, which was mainly attributable to recovery of skin damage during the rest period. Therefore, it can be postulated that the repopulation of the surviving clonogenic epidermal cells is less efficient during continuous daily irradiation than during split course MFD schedule given in the same overall treatment time.
已评估了照射时间的延长及分布作为时间函数对小鼠皮肤再增殖动力学的影响。在4周内，每周5天每天给予20次分割照射，或在3天内每天3次共照射10次，休息19天后重复进行，总时间也为4周。对急性皮肤反应进行了评分。结果发现，每天多次分割照射（MFD）方案引起的皮肤反应比连续每日分割照射少，这主要归因于休息期间皮肤损伤的恢复。因此，可以推测，在相同的总治疗时间内，连续每日照射期间存活的克隆形成表皮细胞的再增殖效率低于分割照射MFD方案期间。
