Shirazi A, Liu K, Trott K R
Department of Radiation Biology, St Bartholomew's Medical College, London, UK.
Int J Radiat Biol. 1995 Aug;68(2):215-21. doi: 10.1080/09553009514551121.
In mouse, a 2 cm long field of both legs was irradiated daily with 3 Gy, five fractions per week for up to 3 weeks. Epidermal morphology, the circadian variation of the labelling index, and repopulation were determined at the end of each week. After a decrease of epidermal cellularity in the first week, excessive regeneration led to hyperplasia and hypertrophy, which continued throughout the experimental period while the residual tolerance of the epidermis to top-up irradiation decreased progressively. Although the repopulation rate was accelerated five-fold, it was unable to compensate the effects of more than two-thirds of the given dose. The hypertrophic and hyperplastic response is attributed to pronounced acceleration of abortive proliferation of doomed stem cells.
在小鼠中，对双腿2厘米长的区域每天照射3戈瑞，每周照射5次，持续3周。在每周结束时测定表皮形态、标记指数的昼夜变化和再增殖情况。在第一周表皮细胞数量减少后，过度再生导致增生和肥大，这种情况在整个实验期间持续存在，而表皮对追加照射的残余耐受性则逐渐降低。尽管再增殖速率加快了五倍，但仍无法补偿超过三分之二给定剂量的影响。肥大和增生反应归因于注定要死亡的干细胞的流产性增殖明显加速。
