Taton G F, Hamar D W, Lewis L D
J Am Vet Med Assoc. 1984 Feb 15;184(4):433-6.
Twenty-four cats were fed a dry commercial cat food once daily for 2 weeks and then ad libitum for 2 weeks. Urine pH was measured 4 times daily the last 3 days of each feeding period. Subsequently, the cats were allotted to 2 equal groups and fed ad libitum an experimental, dry ration with or without 1.5% ammonium chloride for 11 months. During this period, urine pH was measured at 1, 3, 6, and 9 weeks, then monthly through 29 weeks, and then every 6 weeks for the duration of the study. When the cats were fed ad libitum, urine pH remained constant throughout the day, regardless of ration. In cats fed once daily, urine pH increased to 7.6 by 2 hours after feeding and remained between 6.6 and 7.6 for 9 hours. Urine pH remained constant throughout the study when cats were fed the experimental ration with or without 1.5% ammonium chloride, but was significantly different (P less than 0.01) between the 2 groups, 5.9 +/- 0.3 (n = 1,035) and 7.0 +/- 0.5 (n = 616), respectively. Ammonium chloride consumption had no effect on food and water consumption or body weight. It was concluded that ammonium chloride was an effective urinary acidifier for a prolonged time, maintained urine pH below 6.6, and did not decrease food intake when given at a concentration of 1.5% of the diet.
24只猫每天喂食一次市售干猫粮，持续2周，然后自由采食2周。在每个喂食期的最后3天，每天测量4次尿液pH值。随后，将猫分成两组，自由采食含或不含1.5%氯化铵的实验性干日粮，持续11个月。在此期间，在第1、3、6和9周测量尿液pH值，然后在29周内每月测量一次，之后在研究期间每6周测量一次。当猫自由采食时，无论日粮如何，尿液pH值在一天中保持恒定。在每天喂食一次的猫中，喂食后2小时尿液pH值升至7.6，并在9小时内保持在6.6至7.6之间。当猫喂食含或不含1.5%氯化铵的实验日粮时，尿液pH值在整个研究过程中保持恒定，但两组之间有显著差异（P小于0.01），分别为5.9±0.3（n = 1035）和7.0±0.5（n = 616）。氯化铵的摄入对食物和水的消耗或体重没有影响。得出的结论是，氯化铵是一种有效的长效尿液酸化剂，可将尿液pH值维持在6.6以下，且以日粮1.5%的浓度给予时不会减少食物摄入量。
