McLeod R, Estes R G, Mack D G, Cohen H
J Infect Dis. 1984 Feb;149(2):234-44. doi: 10.1093/infdis/149.2.234.
SWR/J mice perorally infected with the Me49 strain of Toxoplasma gondii developed thymic cortical atrophy, clusters of epithelioid cells and plasma cells in lymphoid tissue, and hepatic inflammation during the first month after infection; the inflammation subsequently decreased. Antibody to T gondii was present in serum on day 14 after infection, reached a maximal titer by one month, and remained at this titer for five months. Splenic lymphocyte blastogenesis in response to concanavalin A was depressed for one month but returned to normal in most mice by two months. Splenic lymphocyte blastogenesis in response to toxoplasma antigens (stimulation index, greater than or equal to 1.6) developed in one-third of mice after two months of infection but did not develop in others even after five months of infection. Peritoneal macrophages had an enhanced microbicidal capacity against T gondii from 14 days until five months after infection. Peroral administration of the Me49 strain of T gondii was lethal for Beige-C57BL/6J and C57BL/6J mice; these strains of mice showed the most extensive changes, necrosis, thrombi, and many trophozoites in tissues.
经口感染刚地弓形虫Me49株的SWR/J小鼠在感染后的第一个月出现胸腺皮质萎缩、淋巴组织中上皮样细胞和浆细胞簇以及肝脏炎症；随后炎症减轻。感染后第14天血清中出现抗弓形虫抗体，1个月时达到最高滴度，并在5个月内维持该滴度。对伴刀豆球蛋白A反应的脾淋巴细胞增殖在1个月内受到抑制，但大多数小鼠在2个月时恢复正常。感染2个月后，三分之一的小鼠出现对弓形虫抗原反应的脾淋巴细胞增殖（刺激指数大于或等于1.6），但其他小鼠即使在感染5个月后也未出现。从感染后14天到5个月，腹腔巨噬细胞对弓形虫的杀菌能力增强。经口给予刚地弓形虫Me49株对米色C57BL/6J和C57BL/6J小鼠是致命的；这些品系的小鼠组织中出现最广泛的变化、坏死、血栓和许多滋养体。
