Henry L, Beverley J K
Virchows Arch B Cell Pathol. 1976 Feb 11;20(1):55-69. doi: 10.1007/BF02890326.
Groups of mice were inoculated with strains of Toxoplasma gondii of either high or low virulence strains. The response of the lymph nodes, speen and thymus was studied histologically and antibodies were assessed by the dye-test technique. The low-virulence strain induced changes in all three organs indicative of an immunological response, both in respect of cellular and humoral immunity. The high-virulence strain produced rapid lymphoid depletion in lymph nodes, spleen and thymus with areas of necrosis. It is suggested that the high-virulence strain has a toxic effect on the Reticulo-Endothelial system allowing urestricted proliferation of the organism with eventual death.
将小鼠分组，用高毒力或低毒力的弓形虫菌株进行接种。对淋巴结、脾脏和胸腺的反应进行组织学研究，并通过染料试验技术评估抗体。低毒力菌株在细胞免疫和体液免疫方面均诱导了所有三个器官的变化，表明存在免疫反应。高毒力菌株导致淋巴结、脾脏和胸腺快速淋巴细胞耗竭并出现坏死区域。有人提出，高毒力菌株对网状内皮系统有毒性作用，使该生物体不受限制地增殖，最终导致死亡。
