Harris J R, Recht A, Amalric R, Calle R, Clark R M, Reid J G, Spitalier J M, Vilcoq J R, Hellman S
J Clin Oncol. 1984 Jan;2(1):37-41. doi: 10.1200/JCO.1984.2.1.37.
The frequency, time course, and prognosis of local recurrence following primary radiation therapy in 152 patients with early breast cancer treated before 1967 were examined. Local recurrence occurred at a constant rate over the first 14 years after treatment. The crude 15-year local recurrence rate was 22%. Of the 30 patients who developed an isolated local recurrence and underwent definitive secondary surgery, the 10-year freedom from distant relapse rate was 50%. These results indicate that breast cancer patients treated by primary radiation therapy require long-term follow-up to detect curable local recurrences.
对1967年前接受治疗的152例早期乳腺癌患者进行了初次放射治疗后局部复发的频率、时间进程和预后研究。治疗后的前14年，局部复发以恒定速率发生。15年的粗局部复发率为22%。在30例发生孤立性局部复发并接受确定性二次手术的患者中，10年无远处复发率为50%。这些结果表明，接受初次放射治疗的乳腺癌患者需要长期随访以发现可治愈的局部复发。
