• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Binding of [3H]gamma-vinyl-GABA to GABA-transaminase in brain homogenates.

作者信息

Gale K

出版信息

Life Sci. 1984 Feb 13;34(7):701-6. doi: 10.1016/0024-3205(84)90235-2.

DOI:10.1016/0024-3205(84)90235-2
PMID:6700374
Abstract

[3H]Gamma-vinyl-GABA, an irreversible inhibitor of GABA-transaminase, was used to label the enzyme in homogenates of rat brain. The binding procedure utilized was found to be specific for GABA-transaminase and linear with tissue obtained from several regions of rat brain up to concentrations of 8 micrograms protein/microliter. The specific binding was directly proportional to the activity of the enzyme measured in vitro and was completely inhibited by the GABA-transaminase inhibitors aminooxyacetic acid (100 microM) and 3-mercaptopropionic acid (1.0mM). The binding procedure was used to estimate the amount of active enzyme present in a homogenate of striatal tissue.

摘要

相似文献

1
Binding of [3H]gamma-vinyl-GABA to GABA-transaminase in brain homogenates.
Life Sci. 1984 Feb 13;34(7):701-6. doi: 10.1016/0024-3205(84)90235-2.
2
GABAergic regulation of striatal opioid gene expression.纹状体阿片类基因表达的γ-氨基丁酸能调节
Brain Res Mol Brain Res. 1991 Apr;10(1):49-54. doi: 10.1016/0169-328x(91)90055-3.
3
Synergistic anticonvulsant effects of GABA-T inhibitors and glycine.
Naunyn Schmiedebergs Arch Pharmacol. 1984 May;326(1):49-57. doi: 10.1007/BF00518778.
4
3-Mercaptopropionic acid: convulsant properties, effects on enzymes of the gamma-aminobutyrate system in mouse brain and antagonism by certain anticonvulsant drugs, aminooxyacetic acid and gabaculine.3-巯基丙酸：惊厥特性、对小鼠脑内γ-氨基丁酸系统酶的影响以及某些抗惊厥药物（氨氧基乙酸和加巴脲）的拮抗作用。
Biochem Pharmacol. 1979 Apr 15;28(8):1397-407. doi: 10.1016/0006-2952(79)90443-x.
5
Effects of the gamma-aminobutyrate transaminase inhibitors gabaculine and gamma-vinyl GABA on gamma-aminobutyric acid release from slices of rat cerebral cortex.γ-氨基丁酸转氨酶抑制剂加巴库林和γ-乙烯基γ-氨基丁酸对大鼠大脑皮层切片中γ-氨基丁酸释放的影响。
Neurochem Res. 1987 Jan;12(1):49-52. doi: 10.1007/BF00971363.
6
Contrasting effects of the GABA transaminase inhibitors gamma-vinylGABA and aminooxyacetic acid on arterial pressure following injection into nucleus tractus solitarius.将γ-乙烯基氨基丁酸和氨氧基乙酸这两种γ-氨基丁酸转氨酶抑制剂注射到孤束核后对动脉血压的不同影响。
Neuropharmacology. 1993 Jun;32(6):575-9. doi: 10.1016/0028-3908(93)90053-6.
7
Iron concentration reduced in ventral pallidum, globus pallidus, and substantia nigra by GABA-transaminase inhibitor, gamma-vinyl GABA.γ-乙烯基 GABA（一种γ-氨基丁酸转氨酶抑制剂）可降低腹侧苍白球、苍白球和黑质中的铁浓度。
Brain Res. 1985 Sep 2;342(1):18-25. doi: 10.1016/0006-8993(85)91348-4.
8
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.大脑中γ-氨基丁酸的细胞区室及其与抗惊厥活性的关系。
Mol Cell Biochem. 1981 Sep 25;39:305-29. doi: 10.1007/BF00232582.
9
Potential antidepressant properties of subchronic GABA transaminase inhibitors in the forced swimming test in mice.亚慢性γ-氨基丁酸转氨酶抑制剂在小鼠强迫游泳试验中的潜在抗抑郁特性。
Neuropsychobiology. 1989;21(3):152-6. doi: 10.1159/000118569.
10
Acute effects of gamma-vinyl GABA on the GABAergic system in rats as studied by microdialysis.
Eur J Pharmacol. 1992 Dec 15;229(2-3):269-72. doi: 10.1016/0014-2999(92)90566-m.

引用本文的文献

1
Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state.点燃大鼠适应渗透状态变化时黑质中γ-氨基丁酸代谢及癫痫易感性的改变。
Neurochem Res. 1991 Mar;16(3):269-78. doi: 10.1007/BF00966090.