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越南服役经历与先天性异常风险。一项病例对照研究。

Vietnam service and the risk of congenital anomalies. A case-control study.

作者信息

Donovan J W, MacLennan R, Adena M

出版信息

Med J Aust. 1984 Mar 31;140(7):394-7. doi: 10.5694/j.1326-5377.1984.tb108096.x.

DOI:10.5694/j.1326-5377.1984.tb108096.x
PMID:6700507
Abstract

Infants with anomalies diagnosed at, or shortly after, birth were individually matched to control infants born without an anomaly, in the same hospital, to a mother of similar age, and at about the same date. The fathers in 8517 such case-control pairs were identified, and compared with a list of men who served in the Australian Army between 1962 and 1972 - the period of Australian involvement in Vietnam. Fathers identified as having served in the Army during this period were then classified according to whether or not they had served in Vietnam. One hundred and twenty-seven fathers of infants who were born with anomalies and 123 fathers of control infants were Vietnam veterans. The risk of a Vietnam veteran fathering a child with an anomaly, compared with that of a non-veteran, was estimated at 1.02, with 95% confidence limits of 0.78 to 1.32. There was no evidence that Army service in Vietnam increases the risk of fathering children with anomalies diagnosed at birth.

摘要

在出生时或出生后不久被诊断出患有先天性异常的婴儿,与同一家医院出生的、母亲年龄相仿且出生日期相近的无先天性异常的对照婴儿进行个体匹配。确定了8517对这样的病例对照中的父亲,并与1962年至1972年(澳大利亚参与越南战争的时期)在澳大利亚军队服役的男性名单进行比较。在此期间被确定曾在军队服役的父亲随后根据是否在越南服役进行分类。127名患有先天性异常婴儿的父亲和123名对照婴儿的父亲是越战退伍军人。与非退伍军人相比,越战退伍军人育有先天性异常孩子的风险估计为1.02,95%置信区间为0.78至1.32。没有证据表明在越南服兵役会增加生育出生时被诊断患有先天性异常孩子的风险。

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