美国越战退伍女兵的妊娠结局。
Pregnancy outcomes among U.S. women Vietnam veterans.
作者信息
Kang H K, Mahan C M, Lee K Y, Magee C A, Mather S H, Matanoski G
机构信息
Environmental Epidemiology Service, Veterans Health Administration Department of Veterans Affairs, Washington, DC 20036-3406, USA.
出版信息
Am J Ind Med. 2000 Oct;38(4):447-54. doi: 10.1002/1097-0274(200010)38:4<447::aid-ajim11>3.0.co;2-j.
BACKGROUND
Since the 1965-1975 Vietnam War, there has been persistent concern that women who served in the U.S. military in Vietnam may have experienced adverse pregnancy outcomes.
METHODS
We compared self-reported pregnancy outcomes for 4,140 women Vietnam veterans with those of 4,140 contemporary women veterans who were not deployed to Vietnam. As a measure of association, we calculated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression adjusting for age at conception, race, education, military nursing status, smoking, drinking and other exposures during pregnancy.
RESULTS
There was no statistically significant association between military service in Vietnam and index pregnancies resulting in miscarriage or stillbirth, low birth weight, pre-term delivery, or infant death. The risk of having children with "moderate-to-severe" birth defects was significantly elevated among Vietnam veterans (adjusted OR = 1.46, 95% CI = 1.06-2.02).
CONCLUSIONS
The risk of birth defects among index children was significantly associated with mother's military service in Vietnam.
背景
自1965年至1975年越南战争以来，人们一直担心曾在美国军队中服役于越南的女性可能经历不良妊娠结局。
方法
我们将4140名越南战争退伍女兵自我报告的妊娠结局与4140名未被部署到越南的当代退伍女兵的妊娠结局进行了比较。作为关联度的一种衡量指标，我们使用逻辑回归计算优势比（OR）和95%置信区间（CI），并对受孕时年龄、种族、教育程度、军事护理状况、吸烟、饮酒及孕期其他暴露因素进行了校正。
结果
在越南服役与导致流产或死产、低出生体重、早产或婴儿死亡的索引妊娠之间没有统计学上的显著关联。在越南战争退伍女兵中，生育“中度至重度”出生缺陷孩子的风险显著升高（校正后OR = 1.46，95%CI = 1.06 - 2.02）。
结论
索引儿童的出生缺陷风险与母亲在越南的军事服役显著相关。
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