Azuma T, Koyama Y, Tozawa K
Contrib Nephrol. 1977;6:34-42.
Glomerular selectivity is still conserved in chronic renal failure (CRF), although it is poor when compared with non-CRF. In addition, clearances per unit nephron of 15 plasma proteins (Cprot./Ccr X 100) are markedly elevated in CRF. This reflects an effect of osmotic diuresis on tubular reabsorption of proteins, which may partially account for the tubular dysfunction shown by the augmented excretion of the low molecular proteins, such as lysozyme and insulin. Besides this, there exists certainly tubular damage, since tubuloglomerular protein ratio (Clysozyme/Ctransferrin) rises with the progress of glomerular injury.
慢性肾衰竭（CRF）时肾小球选择性依然存在，尽管与非CRF相比其功能较差。此外，CRF时15种血浆蛋白的单位肾单位清除率（Cprot./Ccr×100）显著升高。这反映了渗透性利尿对肾小管蛋白质重吸收的影响，这可能部分解释了低分子蛋白质（如溶菌酶和胰岛素）排泄增加所显示的肾小管功能障碍。除此之外，肾小管损伤肯定存在，因为肾小管-肾小球蛋白比率（C溶菌酶/C转铁蛋白）随着肾小球损伤的进展而升高。
