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Mechanism of aprindine induced agranulocytosis: direct toxicity on CFU-C and CFU-GEMM.

作者信息

Boogaerts M A, Peters M, Peersman C, Kesteloot H, Verwilghen R L

出版信息

Scand J Haematol. 1984 Feb;32(2):175-8. doi: 10.1111/j.1600-0609.1984.tb02174.x.

DOI:10.1111/j.1600-0609.1984.tb02174.x
PMID:6701462
Abstract

The in vitro bone marrow growth of 2 patients with aprindine-induced agranulocytosis was studied. Granulocyte-macrophage committed stem cell (CFU-C) growth is inhibited by aprindine in a dose dependent manner. 50% inhibition of CFU-colony growth (TD50) was seen at 5.1 and 3.4 micrograms aprindine/ml medium respectively. The TD50 of control marrow CFU-C was 3.2 micrograms/ml. 100% inhibition was seen at 16 micrograms aprindine/ml, both in patients and controls. Pluripotential stem cell growth (CFU-GEMM) in control marrow was equally inhibited in a dose dependent manner by aprindine, though to a lesser extent (TD50: 9.1 micrograms/ml) and with relative sparing of pure megakaryocyte and erythroid colonies. Co-culturing of patients marrows with their respective acute phase serum did not inhibit CFU-C growth.

摘要

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