[Glomerular changes in interstitial kidney diseases].

49 kidney specimens of patients with primary interstitial kidney disease (hydronephrosis in 12, tubulo-interstitial nephritis in 13, analgesic nephropathy in 10, adult polycystic renal disease in 9, oxalosis in 4, and renal dysplasia in 1) were examined for glomerular lesions. Light microscopic investigation showed severe focally and segmentally accentuated glomerular changes in 13 cases (27%). Lesions resembling focal sclerosis were found in 11 cases and focal-segmental mesangial proliferation in 2 cases. The results reveal that glomerular lesions occur frequently in primary interstitial kidney disease and can be found in all of the above-mentioned diagnostic entities.