Basu A, Chakrabarty K, Haldar S, Addya S, Chatterjee G C
Toxicol Lett. 1984 Mar;20(3):303-8. doi: 10.1016/0378-4274(84)90164-4.
Acute i.p. administration of lanthanum chloride to newborn chicks at a single dose of 250 mg/kg body weight causes inhibition of the high affinity uptake of [14C]glutamate by isolated brain synaptosomes. There is also a marked decrease in the release of preloaded [14C]glutamate from brain synaptosomes in the presence of externally available Ca2+ (1.2 mM) or a high K+ concentration (71 mM). The inhibition of glutamate release has been discussed in relation to depletion of Ca2+ binding to the synaptosomal membrane under lanthanum intoxication.
以250毫克/千克体重的单剂量向新生雏鸡腹腔内急性注射氯化镧，会抑制离体脑突触体对[14C]谷氨酸的高亲和力摄取。在存在外部可利用的Ca2+（1.2毫摩尔）或高钾浓度（71毫摩尔）的情况下，预加载的[14C]谷氨酸从脑突触体的释放也显著减少。已经讨论了镧中毒时谷氨酸释放的抑制与突触体膜上Ca2+结合的耗竭有关。
