抗体结合位点可以通过合成来模拟。针对维生素K1的γ-羟基衍生物的免疫球蛋白新结合位点的表面模拟合成。 - Suppr

Suppr

超能文献

Antibody-combining sites can be mimicked synthetically. Surface-simulation synthesis of the immunoglobulin new combining site to the gamma-hydroxyl derivative of vitamin K1.

作者信息

Twining S S, Atassi M Z

出版信息

J Biol Chem. 1978 Aug 10;253(15):5259-62.

PMID:670193

Abstract

摘要

相似文献

Antibody-combining sites can be mimicked synthetically. Surface-simulation synthesis of the immunoglobulin new combining site to the gamma-hydroxyl derivative of vitamin K1.抗体结合位点可以通过合成来模拟。针对维生素K1的γ-羟基衍生物的免疫球蛋白新结合位点的表面模拟合成。

J Biol Chem. 1978 Aug 10;253(15):5259-62.

Antibody combining sites can be mimicked synthetically. Surface-simulation synthesis of the phosphorylcholine-combining site of myeloma protein M-603.抗体结合位点可以通过合成来模拟。骨髓瘤蛋白M-603磷酸胆碱结合位点的表面模拟合成。

Biochem J. 1980 Jun 1;187(3):661-6. doi: 10.1042/bj1870661.

The antibody combining site.

Sci Am. 1977 Jan;236(1):50-9. doi: 10.1038/scientificamerican0177-50.

Modeling of antibody combining sites.

Methods Enzymol. 1991;203:3-21. doi: 10.1016/0076-6879(91)03003-y.

Molecular modeling of antibody-combining sites.抗体结合位点的分子建模。

Methods Mol Biol. 1995;51:17-49. doi: 10.1385/0-89603-275-2:17.

The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.免疫球蛋白 NEW 结合区域 - 配体复合物在 3.5 埃分辨率下的三维结构。

Proc Natl Acad Sci U S A. 1974 Apr;71(4):1427-30. doi: 10.1073/pnas.71.4.1427.

Studies on the three-dimensional structure of immunoglobulins.免疫球蛋白三维结构的研究。

Prog Biophys Mol Biol. 1976;31(1):67-93. doi: 10.1016/0079-6107(78)90005-6.

Ineffectiveness of phylloquinone epoxide as an inhibitor of prothrombin synthesis in the rat.

Biochem Biophys Res Commun. 1974 Nov 6;61(1):250-7. doi: 10.1016/0006-291x(74)90560-9.

Can an antibody-combining site be mimicked synthetically? The possible surface simulation synthesis of two antibody-combining sites complementary to two antigenic sites of lysozyme.抗体结合位点能否通过合成进行模拟？针对溶菌酶两个抗原位点的两个抗体结合位点的可能表面模拟合成。

J Biol Chem. 1977 Dec 25;252(24):8784-7.

Nuclear vitamin K2 binding protein in human osteoblasts: homologue to glyceraldehyde-3-phosphate dehydrogenase.人成骨细胞中的核维生素K2结合蛋白：与甘油醛-3-磷酸脱氢酶同源。

Biochem Pharmacol. 1999 Nov 15;58(10):1631-8. doi: 10.1016/s0006-2952(99)00236-1.

引用本文的文献

Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites exhibit the activity and specificity of the respective enzyme.肽酶（pepzyme）的设计：模拟胰凝乳蛋白酶和胰蛋白酶活性位点的表面模拟合成肽表现出相应酶的活性和特异性。

Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8282-6. doi: 10.1073/pnas.90.17.8282.

Haemoglobin binding with haptoglobin. Localization of the haptoglobin-binding site on the alpha-chain of human haemoglobin.血红蛋白与触珠蛋白的结合。触珠蛋白结合位点在人血红蛋白α链上的定位。

Biochem J. 1981 Aug 1;197(2):507-10. doi: 10.1042/bj1970507.

Binding with lysozyme of antibodies against surface-simulation peptides representing the lysozyme antigenic sites.针对代表溶菌酶抗原位点的表面模拟肽的抗体与溶菌酶的结合。

Biochem J. 1982 Mar 1;201(3):669-72. doi: 10.1042/bj2010669.

Localization and synthesis of the acetylcholine-binding site in the alpha-chain of the Torpedo californica acetylcholine receptor.加州电鳐乙酰胆碱受体α链中乙酰胆碱结合位点的定位与合成

Biochem J. 1984 Dec 15;224(3):995-1000. doi: 10.1042/bj2240995.

Biochem J. 1980 Jun 1;187(3):661-6. doi: 10.1042/bj1870661.

The antibody response to myoglobin is independent of the immunized species. Analysis in terms of replacements in the antigenic sites and in environmental residues of the cross-reactions of fifteen myoglobins with sperm-whale myoglobin antisera raised in different species.对肌红蛋白的抗体反应与免疫物种无关。分析了在不同物种中产生的十五种肌红蛋白与抹香鲸肌红蛋白抗血清交叉反应的抗原位点和环境残基中的替换情况。

Biochem J. 1980 Dec 1;191(3):681-97. doi: 10.1042/bj1910681.

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.蛋白质抗原结构的精确测定揭示了蛋白质的分子免疫识别，并为其他蛋白质结合位点的合成模拟提供了原型。

Mol Cell Biochem. 1980 Aug 29;32(1):21-43. doi: 10.1007/BF00421293.

Surface-simulation synthesis of the substrate-binding site of an enzyme. Demonstration with trypsin.酶底物结合位点的表面模拟合成。以胰蛋白酶为例进行演示。

Biochem J. 1985 Mar 1;226(2):477-85. doi: 10.1042/bj2260477.

Antigen-binding specificities of antibodies are primarily determined by seven residues of VH.抗体的抗原结合特异性主要由重链可变区（VH）的七个残基决定。

Proc Natl Acad Sci U S A. 1985 May;82(9):2945-9. doi: 10.1073/pnas.82.9.2945.

Subunit interacting surfaces of human haemoglobin. Localization of the alpha-subunit-beta-subunit interacting surfaces on the beta-chain by a comprehensive synthetic strategy.人血红蛋白的亚基相互作用表面。通过综合合成策略确定β链上α亚基与β亚基的相互作用表面。

Biochem J. 1986 Mar 1;234(2):457-61. doi: 10.1042/bj2340457.

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