Reich W, Wagner F, Hofmann K D, Marzotko F, Schmeisser G
Zentralbl Gynakol. 1984;106(3):196-200.
In the tissue of 54 ovarian carcinomas and 38 normal human ovaries the activity of cathepsin D was determined by means of the Anson-method. In ovarian carcinomas the mean activity of cathepsin D was 4515 pmol T/s/g tissue, in normal ovarian tissue only 2119 pmol T/s/g. The difference is significant (p less than 0,001). The dependency on age of the activity of cathepsin D suitable for normal ovary, got lost in cancer tissue. There is no relationship between the amount of activity of cathepsin D and the stage of the tumour. Extreme high activities of cathepsin D were found in metastatic ovarian carcinomas. The activity of cathepsin D is higher in endometrioid and papillary than in mucigenous and hypernephroid ovarian carcinomas. The different activities of cathepsin D were discussed with regard to the invasive growth of cancer and to deranged protein metabolism.
采用安森法测定了54例卵巢癌组织及38例正常人类卵巢组织中组织蛋白酶D的活性。卵巢癌组织中组织蛋白酶D的平均活性为4515 pmol T/s/g组织，而正常卵巢组织中仅为2119 pmol T/s/g。差异具有显著性（p<0.001）。正常卵巢中组织蛋白酶D活性对年龄的依赖性在癌组织中消失。组织蛋白酶D的活性量与肿瘤分期之间没有关系。在转移性卵巢癌中发现组织蛋白酶D活性极高。子宫内膜样癌和乳头状癌中组织蛋白酶D的活性高于黏液性癌和肾样癌。就癌症的侵袭性生长和蛋白质代谢紊乱讨论了组织蛋白酶D的不同活性。
