Stranden E
Acta Chir Scand. 1984;150(1):25-30.
Ultrasound Doppler flowmetry during local exposure to subatmospheric pressure (limb negative pressure exposure--LNPE) was used to study the effect of increased transmural pressure on femoral artery blood flow. Twelve healthy controls and patients with lower limb atherosclerosis--before (n = 11) and after (n = 18) femoropopliteal reconstruction were included in the study. One minute after onset of LNPE blood flow in the common femoral artery was reduced by 46% in controls, which implies increased arterial tone at increased transmural pressure (veno-arteriolar vasoconstrictor response). In patients with lower limb atherosclerosis the average blood flow during LNPE was not different from blood flow at rest. In 3 patients with pain at rest blood flow increased 25% during exposure, indicating reduced arterial tone. This finding is consistent with the clinical experience that patients with ischemic pain find relief by lowering their legs. Following femoropopliteal reconstruction the vasoconstrictor response was absent during the first days; but appeared approximately one week postoperatively. Thus impaired arteriolar regulatory mechanisms may be one causative factor for the initial formation of local edema frequently observed after arterial reconstruction.
在局部处于低于大气压的压力环境下（肢体负压暴露——LNPE）使用超声多普勒血流仪，以研究跨壁压力增加对股动脉血流的影响。该研究纳入了12名健康对照者以及患有下肢动脉粥样硬化的患者——股腘动脉重建术前（n = 11）和术后（n = 18）。LNPE开始1分钟后，健康对照者股总动脉的血流减少了46%，这意味着在跨壁压力增加时动脉张力增加（静脉 - 小动脉血管收缩反应）。在患有下肢动脉粥样硬化的患者中，LNPE期间的平均血流与静息血流无差异。在3名静息时疼痛的患者中，暴露期间血流增加了25%，表明动脉张力降低。这一发现与临床经验相符，即患有缺血性疼痛的患者通过垂下双腿可缓解疼痛。股腘动脉重建术后的头几天没有血管收缩反应；但大约在术后一周出现。因此，小动脉调节机制受损可能是动脉重建后经常观察到的局部水肿最初形成的一个致病因素。
