Mann J J, Stanley M
Acta Psychiatr Scand. 1984 Feb;69(2):135-9. doi: 10.1111/j.1600-0447.1984.tb02477.x.
Serotonin, a preferred monoamine oxidase (MAO) A substrate may be deficient centrally in suicide victims. In postmortem samples of frontal cortex from suicide victims we demonstrated receptor changes in the serotonergic system supportive of this hypothesis. These changes were not accompanied in this series of brain samples by alterations in either MAO A or B enzyme kinetics. Thus brain MAO A is not a useful indicator of altered serotonergic function in suicide victims. We did confirm an age-related increase in cortical MAO B but not MAO A enzyme concentrations in both controls and suicide victims.
血清素是单胺氧化酶（MAO）A的首选底物，自杀受害者大脑中可能缺乏血清素。在自杀受害者额叶皮质的尸检样本中，我们证实了血清素能系统中的受体变化，这支持了这一假说。在这一系列脑样本中，MAO A或B的酶动力学均未发生改变。因此，大脑中的MAO A并非自杀受害者血清素能功能改变的有用指标。我们确实证实，在对照组和自杀受害者中，皮质MAO B的酶浓度均随年龄增长而升高，但MAO A则不然。
