Corrigan J J
Am J Dis Child. 1984 Mar;138(3):240-2. doi: 10.1001/archpedi.1984.02140410020008.
Coagulation studies were performed on 16 children with gram-negative septicemia without the complications of septic shock, liver disease, malnutrition, or laboratory evidence of classic disseminated intravascular coagulation (DIC). Ten (63%) of the 16 cases were found to have abnormal partial thromboplastin and/or prothrombin times. The coagulopathy was caused by a reduction in the vitamin K-dependent coagulation factors. The mechanism that produced this coagulopathy was not known, but evidence was found that suggested that endotoxin may interfere with the vitamin K-carboxylation reaction. The data indicated that abnormal coagulation screening test results in children with gram-negative septicemia were not specific for DIC and that a significant number of patients had a coagulopathy not related to DIC.
对16例革兰氏阴性菌败血症患儿进行了凝血研究，这些患儿无感染性休克、肝病、营养不良并发症，也无典型弥散性血管内凝血（DIC）的实验室证据。16例中有10例（63%）发现部分凝血活酶时间和/或凝血酶原时间异常。凝血病是由维生素K依赖的凝血因子减少所致。产生这种凝血病的机制尚不清楚，但有证据表明内毒素可能干扰维生素K羧化反应。数据表明，革兰氏阴性菌败血症患儿凝血筛查试验结果异常并非DIC所特有，相当数量的患者存在与DIC无关的凝血病。
