Benedet J L, Sanders B H
Am J Obstet Gynecol. 1984 Mar 1;148(5):695-700. doi: 10.1016/0002-9378(84)90776-2.
A review was made of 136 cases of carcinoma in situ of the vagina seen over a 30-year period, 1953 to 1982. The patients ranged in age from 17 to 77 years, with a mean age of 55 years. One hundred sixteen patients (85%) presented with an abnormal Papanicolaou smear. Colposcopically directed biopsies were used for diagnosis in 62% of the patients. The upper one third of the vagina was the most common site of disease, with 54% of patients having unifocal lesions. A previous hysterectomy had been performed in 71% of patients, 35% of whom had undergone operation for benign disease. A concomitant, subsequent, or prior neoplasm of the lower genital tract or pelvis was noted in 109 patients. Surgical intervention in the form of either wide local excision or partial or total vaginectomy was the most frequently used method of treatment. Radiotherapy, usually in the form of a vaginal mold, was the second most commonly used method of treatment, and it was used in 27 patients. Radiotherapy and more extensive surgical treatment methods gave the best results. Four patients subsequently developed invasive carcinoma of the vagina.
回顾了1953年至1982年这30年间所见的136例阴道原位癌病例。患者年龄在17岁至77岁之间，平均年龄为55岁。116例患者（85%）巴氏涂片异常。62%的患者采用阴道镜引导下活检进行诊断。阴道上三分之一是最常见的病变部位，54%的患者为单发病灶。71%的患者曾行子宫切除术，其中35%是因良性疾病接受手术。109例患者存在下生殖道或盆腔的同时性、后续性或先前性肿瘤。最常用的治疗方法是广泛局部切除或部分或全阴道切除术等手术干预。放疗通常采用阴道模具的形式，是第二常用的治疗方法，27例患者接受了放疗。放疗和更广泛的手术治疗方法效果最佳。4例患者随后发生了阴道浸润癌。
