突触后致密物的形态。一项连续切片研究。
Form of the postsynaptic density. A serial section study.
作者信息
Cohen R S, Siekevitz P
出版信息
J Cell Biol. 1978 Jul;78(1):36-46. doi: 10.1083/jcb.78.1.36.
Abstract
Through the use of serial sectioning of dog cerebral cortex tissue, holes or perforations could be revealed in the larger postsynaptic densities (PSDs), in confirmation of the earlier work of Peters and Kaisermann-Abramof (1969. Z. Zellforsch. Mikrosk. Anat. 100:487-506). These holes appeared in serial sections which happened to be cut both parallel and normal to the plane of the synaptic junction. Cleft material was absent in that part of the synaptic cleft opposite this hole. Somestimes the presynaptic membrane opposite the hole was indented into the presynaptic cell. In addition, most of the synaptic vesicles in the presynaptic cell close to the membrane were clustered at that part of the membrane opposite the edge of the density disk. The meaning of the hole and of the other features mentioned above for the function of the density is not known at present.
摘要
通过对犬大脑皮质组织进行连续切片，可在较大的突触后致密物（PSD）中发现孔洞或穿孔，这证实了彼得斯和凯泽曼 - 阿布拉莫夫早期的研究工作（1969年。《细胞研究杂志：显微镜解剖学》100:487 - 506）。这些孔洞出现在恰巧与突触连接平面平行和垂直切割的连续切片中。在该孔洞相对的突触间隙部分没有缝隙物质。有时，孔洞相对的突触前膜会凹入突触前细胞。此外，靠近膜的突触前细胞中的大多数突触小泡聚集在与致密盘边缘相对的膜的那一部分。目前尚不清楚上述孔洞及其他特征对于致密物功能的意义。
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