Young R C, Alexopoulos G S, Shamoian C A, Dhar A K, Kutt H
Am J Psychiatry. 1984 Mar;141(3):432-3. doi: 10.1176/ajp.141.3.432.
The authors describe a patient who developed congestive heart failure and had a high plasma concentration of 10-hydroxynortriptyline. They discuss the need for further research to define the contribution of antidepressants' active metabolites to toxic and therapeutic effects.
作者描述了一名出现充血性心力衰竭且血浆中10-羟基去甲替林浓度很高的患者。他们讨论了进一步开展研究以明确抗抑郁药的活性代谢产物对毒性和治疗效果影响的必要性。