Fiserova-Bergerova V
Anesth Analg. 1984 Apr;63(4):399-404.
The effect of isoflurane upon halothane metabolism was studied in rats exposed to mixtures of subanesthetic concentrations of isoflurane (0.015-0.32%) and halothane (0.062%). The extent of halothane metabolism was determined from concentrations of halothane and its metabolites (total nonvolatile fluorine, 1,1,1-trifluoro-2-chloroethane and 1,1-difluoro-2-chloroethylene) in tissues of rats. At the end of exposures lasting 3 hr, distribution of halothane in tissues indicated that the bioavailability of halothane in liver was unaffected by exposure to isoflurane. Isoflurane, however, significantly inhibited the oxidative metabolism of halothane, as indicated by reduced concentrations of total nonvolatile fluorine in tissues. The inhibition is concentration-dependent. Isoflurane enhances the reductive metabolism of halothane, as indicated by increased concentrations of volatile metabolites in liver. Exposure to nitrous oxide (2.2-50%) had no effect on halothane metabolism. The mechanism of the inhibitory effect remains to be explained.
在暴露于亚麻醉浓度异氟烷（0.015 - 0.32%）和氟烷（0.062%）混合气体的大鼠中，研究了异氟烷对氟烷代谢的影响。氟烷代谢程度通过大鼠组织中氟烷及其代谢产物（总非挥发性氟、1,1,1 - 三氟 - 2 - 氯乙烷和1,1 - 二氟 - 2 - 氯乙烯）的浓度来确定。在持续3小时的暴露结束时，组织中氟烷的分布表明，肝脏中氟烷的生物利用度不受异氟烷暴露的影响。然而，异氟烷显著抑制了氟烷的氧化代谢，组织中总非挥发性氟浓度降低表明了这一点。这种抑制作用具有浓度依赖性。异氟烷增强了氟烷的还原代谢，肝脏中挥发性代谢产物浓度增加表明了这一点。暴露于氧化亚氮（2.2 - 50%）对氟烷代谢没有影响。这种抑制作用的机制仍有待解释。
