Vána S, Nĕmec J, Zamrazil V, Bednár J
Endokrinologie. 1977 Feb;69(1):67-73.
Diagnostic value of a scope of peripheric parameters of thyroid function was assessed in an unselected group of untreated patients with suspected thyroid disorder, further in untraeted selected patients (without cardiac involvement) and in treated patients. Comparison of relative values of individual tests was performed, based on relation to plasma thyroid hormone level represented by PBI. It was found that: 1. The diagnostic value of heart rate, plasma cholesterol level, B. M. R. and Hegglin's sign (T-2s interval) is of a very limited degree. 2. The diagnostic accuracy of AJT, Q-Kd interval and PEP was found to be of considerable interest even in unselected patients. Values of IRVD and D indices found for these tests are comparable and allow the immediate estimation of thyroid function in bedside diagnosis. 3. The diagnostic value of PEP could be enhanced by exclusion of patients with suspected or proved cardiac disorder or myocardial failure; this may be useful for physiologic studies. 4. While heart rate is profoundly and inconsistently influenced by beta-blockade, AJT is influenced to a minimal degree only and Q-Kd and PEP are uniformly shifted to higher values, allowing thus diagnostic evaluation during this form of treatment also. 5. As Q-Kd is considerably age-and height-dependent, AJT and PEP are believed to be the most suitable test for immediated clinical diagnosis.
在一组未经选择的疑似甲状腺疾病的未治疗患者中，进一步在未经选择的选定患者（无心脏受累）和已治疗患者中评估了一系列甲状腺功能外周参数的诊断价值。基于与以蛋白结合碘（PBI）表示的血浆甲状腺激素水平的关系，对各项检查的相对值进行了比较。结果发现：1. 心率、血浆胆固醇水平、基础代谢率（B.M.R.）和赫格琳征（T-2s间期）的诊断价值非常有限。2. 即使在未经选择的患者中，AJT、Q-Kd间期和PEP的诊断准确性也相当可观。这些检查的IRVD和D指数值具有可比性，可在床边诊断中立即评估甲状腺功能。3. 排除疑似或确诊患有心脏疾病或心肌衰竭的患者可提高PEP的诊断价值；这可能对生理学研究有用。4. 虽然心率受到β受体阻滞剂的深刻且不一致的影响，但AJT仅受到最小程度的影响，而Q-Kd和PEP均统一升高，因此在这种治疗方式下也可进行诊断评估。5. 由于Q-Kd在很大程度上依赖于年龄和身高，AJT和PEP被认为是即时临床诊断最合适的检查。
