Ellenberg J H, Hirtz D G, Nelson K B
Ann Neurol. 1984 Feb;15(2):127-34. doi: 10.1002/ana.410150204.
Age at onset of seizures in young children and its relationship to factors such as prior neurological status and neurological outcome were examined. Of 52,360 children, 39,270 of whom were followed for the full 7 years, a total of 2,635 experienced one or more seizures between birth and 7 years of age. The incidence of nonfebrile convulsions was highest in the first year of life, especially in the first month. Children with neonatal seizures who later developed nonfebrile seizures did so early, two-thirds by 6 months and three-quarters by 1 year of age. Children with neurological or developmental abnormality assessed in the first year of life did not have their first seizure earlier than children without abnormality. Neurological abnormality in the first year of life before any seizure, and the presence of minor motor seizures, were associated with an increased rate of mental retardation and cerebral palsy at age 7, but early age at onset appeared to have little prognostic value regarding intellectual function, cerebral palsy, and epilepsy.
研究了幼儿癫痫发作的起始年龄及其与既往神经状态和神经学转归等因素的关系。在52360名儿童中，其中39270名儿童接受了整整7年的随访，共有2635名儿童在出生至7岁之间经历了一次或多次癫痫发作。非热性惊厥的发病率在出生后的第一年最高，尤其是在第一个月。新生儿期有癫痫发作且后来发展为非热性癫痫发作的儿童发病较早，三分之二在6个月时发病，四分之三在1岁时发病。出生后第一年评估有神经或发育异常的儿童首次癫痫发作时间并不比无异常的儿童早。出生后第一年在任何癫痫发作之前的神经异常以及轻微运动性癫痫发作，与7岁时智力发育迟缓及脑瘫的发生率增加有关，但发病年龄较早似乎对智力功能、脑瘫和癫痫的预后价值不大。
