Clemmensen O J, Olsen P Z, Andersen K E
Arch Dermatol. 1984 Mar;120(3):338-41.
Of six patients treated with thalidomide for either prurigo nodularis or discoid lupus erythematosus, four had paresthesias in the hands and feet and one also complained of muscular pain and stiffness. Clinical neurological findings in all four patients were normal. Subsequent electrophysiological examination disclosed a peripheral neuropathy in five of the six patients; two had electrophysiological signs of a polyneuropathy and three of a carpal tunnel syndrome. Symptoms and abnormal electrophysiological findings were still present in one patient one year after the discontinuation of thalidomide therapy. Since reports on thalidomide neurotoxicity have shown that the neurological symptoms are long standing and possibly irreversible, it is obviously important to inform patients of this possible side effect and to evaluate them closely for the symptoms and electrophysiological signs of evolving neurological changes.
在使用沙利度胺治疗结节性痒疹或盘状红斑狼疮的6例患者中，4例出现手足感觉异常，1例还主诉肌肉疼痛和僵硬。所有4例患者的临床神经学检查结果均正常。随后的电生理检查发现，6例患者中有5例存在周围神经病变；2例有多发性神经病变的电生理体征，3例有腕管综合征的电生理体征。在停止沙利度胺治疗1年后，1例患者的症状和异常电生理表现仍然存在。由于关于沙利度胺神经毒性的报告表明，神经症状持续时间长且可能不可逆，因此告知患者这种可能的副作用并密切评估他们是否出现神经病变进展的症状和电生理体征显然很重要。
