高效液相色谱法快速测定人血浆中的奎尼丁
Rapid determination of quinidine in human plasma by high-performance liquid chromatography.
作者信息
Achari R G, Baldridge J L, Koziol T R, Yu L
出版信息
J Chromatogr Sci. 1978 Jun 10;16(6):271-3. doi: 10.1093/chromsci/16.6.271.
PMID:670374
Abstract
A sensitive and specific method for the determination of quinidine in plasma is described. Quinidine is extracted with chloroform, the extract is evaporated and reconstituted with methanol and the methanol extract is analyzed by high-performance liquid chromatography using a silica gel column. The recovery of quinidine from plasma varied between 93.0 to 100%. Quinidine levels as low as 12 ng/ml can be detected by this method.
摘要
本文描述了一种灵敏且特异的测定血浆中奎尼丁的方法。用氯仿提取奎尼丁，提取物蒸发后用甲醇复溶，甲醇提取物用硅胶柱通过高效液相色谱法进行分析。奎尼丁从血浆中的回收率在93.0%至100%之间。该方法可检测低至12 ng/ml的奎尼丁水平。
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