Wheby M S
Arch Intern Med. 1984 Mar;144(3):621-2.
The pathogenesis of liver damage in patients with iron loading disorders is not explained. Evidence concerning the following hypothesis is reviewed: Iron, absorbed from the intestinal tract when transferrin saturation is complete or almost so, remains unbound and is lost into the liver on first passage through the portal circulation. By still-to-be-determined molecular events, unbound iron is toxic to liver cells and produces progressive damage when this process occurs repeatedly.
铁负荷紊乱患者肝损伤的发病机制尚不清楚。本文综述了关于以下假说的证据：当转铁蛋白饱和度达到或几乎达到饱和时，从肠道吸收的铁仍未结合，在首次通过门静脉循环时进入肝脏并丢失。通过尚未确定的分子事件，未结合的铁对肝细胞有毒性，当这个过程反复发生时会造成进行性损伤。
