O'Neill S, Tipton K F, Prichard J S, Quinlan A
Arch Intern Med. 1984 Mar;144(3):641-2.
A patient survived acute alcohol intoxication with an unprecedented blood alcohol level of 1,500 mg/dL. Treatment included peritoneal dialysis and intravenously administered fructose. Alcohol elimination followed first-order kinetics, in which the elimination rate is proportional to concentration, rather than zero order in which the metabolic rate is independent of concentration. The report provides further evidence for first-order elimination kinetics with high blood alcohol levels and for an adaptive increase in alcohol metabolism with long-term alcohol consumption.
一名患者在血液酒精浓度达到史无前例的1500毫克/分升的情况下从急性酒精中毒中幸存下来。治疗措施包括腹膜透析和静脉注射果糖。酒精消除遵循一级动力学，即消除速率与浓度成正比，而不是零级动力学，零级动力学中代谢速率与浓度无关。该报告为高血液酒精浓度下的一级消除动力学以及长期饮酒导致酒精代谢适应性增加提供了进一步证据。
