Passi S, Picardo M, Nazzaro-Porro M, Breathnach A, Confaloni A M, Serlupi-Crescenzi G
Biochem Pharmacol. 1984 Jan 1;33(1):103-8. doi: 10.1016/0006-2952(84)90376-9.
In isolated rat liver mitochondria, respiration was competitively inhibited by medium chain length (C8 to C13) dicarboxylic acids to different extents: the higher the number of carbon atoms up to C12, the greater the inhibition. In particular, experiments on submitochondrial particles showed that the competitive inhibition concerned the following enzymes: NADH dehydrogenase, succinic dehydrogenase and reduced ubiquinone: cytochrome c oxido-reductase. These results tend to confirm the suggestion that the melanocytotoxic effect of dicarboxylic acids, which are also competitive inhibitors of tyrosinase, may be primarily due to an antimitochondrial effect rather than being tyrosinase-dependent.
在分离的大鼠肝线粒体中，中链长度（C8至C13）的二羧酸对呼吸有不同程度的竞争性抑制作用：碳原子数在C12之前越高，抑制作用越强。特别是，对亚线粒体颗粒的实验表明，这种竞争性抑制涉及以下几种酶：NADH脱氢酶、琥珀酸脱氢酶和还原型泛醌：细胞色素c氧化还原酶。这些结果倾向于证实以下推测，即二羧酸的黑素细胞毒性作用（二羧酸也是酪氨酸酶的竞争性抑制剂）可能主要是由于抗线粒体作用，而非依赖于酪氨酸酶。
