Gutiérrez G, Dagnino R, Mintz G
Arthritis Rheum. 1984 Mar;27(3):291-4. doi: 10.1002/art.1780270307.
Eighteen women with polymyositis/dermatomyositis (PM/DM) were studied to determine the possible influences of pregnancy on the disease and the influence of the disease on pregnancy. Before the onset of PM/DM there were 77 pregnancies: 7 (9%) ended in abortion, 2 (2.5%) in perinatal deaths, with a total fetal loss of 11.5%. There were 3 (3.8%) premature newborns that survived. These figures are equivalent to those of the general population. There were 10 pregnancies in 7 patients coinciding with PM/DM, 1 of them with twins; 3 (30%) ended in abortion, 3 (25%) in perinatal deaths, with a total fetal loss of 55%, and 5 (50%) pregnancies ended prematurely. Four of the 7 women had onset of PM/DM during pregnancy, and 3 others with previously inactive disease had an exacerbation during pregnancy. There were no maternal deaths, nor was there any correlation between activity of PM/DM and fetal loss. These results together with those previously reported suggest that pregnancy in PM/DM should be considered high-risk for both the mother and the baby.
对18名患有多发性肌炎/皮肌炎（PM/DM）的女性进行了研究，以确定妊娠对该疾病的可能影响以及该疾病对妊娠的影响。在PM/DM发病前有77次妊娠：7次（9%）以流产告终，2次（2.5%）为围产期死亡，胎儿总损失率为11.5%。有3例（3.8%）早产新生儿存活。这些数字与普通人群的数字相当。7例患者中有10次妊娠与PM/DM同时发生，其中1次为双胞胎；3次（30%）以流产告终，3次（25%）为围产期死亡，胎儿总损失率为55%，5次（50%）妊娠早产。7名女性中有4名在怀孕期间发生PM/DM，另外3名先前病情不活跃的女性在怀孕期间病情加重。没有孕产妇死亡，PM/DM的活动与胎儿损失之间也没有相关性。这些结果与先前报道的结果表明，PM/DM患者的妊娠对母亲和婴儿都应被视为高风险。
