芬太尼与氟烷辅助全身麻醉对上腹部手术应激反应的比较。

Comparison of fentanyl and halothane supplementation to general anaesthesia on the stress response to upper abdominal surgery.

作者信息

Campbell B C, Parikh R K, Naismith A, Sewnauth D, Reid J L

出版信息

Br J Anaesth. 1984 Mar;56(3):257-61. doi: 10.1093/bja/56.3.257.

DOI:10.1093/bja/56.3.257

Abstract

The stress response to surgery and anaesthesia was studied in 20 patients undergoing cholecystectomy or vagotomy and pyloroplasty. Patients were anaesthetized with thiopentone and nitrous oxide; 10 patients received supplements of 0.5-1.5% halothane and the others fentanyl (mean 17 micrograms kg-1). The plasma concentrations of cortisol and glucose increased in both groups during surgery and remained greater than baseline immediately following recovery of consciousness. The hyperglycaemic response in the halothane group was greater than in the fentanyl group. Plasma noradrenaline concentrations increased in the group receiving halothane, but did not increase significantly in the group receiving fentanyl.

摘要

对20例接受胆囊切除术或迷走神经切断术加幽门成形术的患者进行了手术和麻醉应激反应的研究。患者用硫喷妥钠和氧化亚氮麻醉；10例患者补充0.5 - 1.5%的氟烷，其余患者补充芬太尼（平均17微克/千克）。两组患者在手术期间血浆皮质醇和葡萄糖浓度均升高，意识恢复后立即高于基线水平。氟烷组的高血糖反应大于芬太尼组。接受氟烷的组血浆去甲肾上腺素浓度升高，而接受芬太尼的组未显著升高。