硝苯地平对心绞痛患者红细胞变形能力的急性影响。
The acute effects of nifedipine on red cell deformability in angina pectoris.
作者信息
Waller D G, Nicholson H P, Roath S
出版信息
Br J Clin Pharmacol. 1984 Feb;17(2):133-8. doi: 10.1111/j.1365-2125.1984.tb02327.x.
Abstract
In a randomised double-blind study, the effects on red cell deformability of a single sublingual dose of nifedipine were compared with placebo in eight patients with stable angina pectoris. Red cell deformability, measured by filtration and centrifugation techniques, was significantly increased at rest in all eight patients 1 h after nifedipine, while no change occurred after placebo. The improvement in deformability after nifedipine was maintained at the end of a period of exercise and unchanged from resting values after placebo. The results suggest that the increased deformability of red cells after nifedipine could contribute to the therapeutic effects of the drug in myocardial ischaemia.
摘要
在一项随机双盲研究中，将8例稳定型心绞痛患者单次舌下含服硝苯地平对红细胞变形性的影响与安慰剂进行了比较。通过过滤和离心技术测量红细胞变形性，结果显示，服用硝苯地平1小时后，所有8例患者静息时的红细胞变形性均显著增加，而服用安慰剂后无变化。运动结束时，硝苯地平组红细胞变形性的改善得以维持，而安慰剂组则与静息值无变化。结果表明，硝苯地平后红细胞变形性增加可能有助于该药物对心肌缺血的治疗作用。
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