T-2毒素与小鼠淋巴细胞的相互作用。

Interaction of T-2 toxin with murine lymphocytes.

作者信息

Gyongyossy-Issa M I, Khachatourians G G

出版信息

Biochim Biophys Acta. 1984 Mar 23;803(3):197-202. doi: 10.1016/0167-4889(84)90010-7.

Abstract

T-2 toxin is taken up by lymphocytes in 10-15 min in a saturable manner. Uptake is dependent on temperature and partially on the availability of energy. Approx. 10(5) molecules of T-2 toxin are bound per cell, having a mean affinity constant, Ka = 1.6 X 10(7) M-1. The toxin is rapidly dissociated from the cell to leave approx. 10-15% of the original loading in 1 h. It is concluded that T-2 toxin uptake and release do not follow conventional mechanisms.

摘要

T-2毒素在10 - 15分钟内以可饱和的方式被淋巴细胞摄取。摄取取决于温度，部分取决于能量的可用性。每个细胞大约结合10⁵个T-2毒素分子，平均亲和常数Ka = 1.6×10⁷ M⁻¹。毒素迅速从细胞中解离，1小时后留下约10 - 15%的原始负载量。结论是T-2毒素的摄取和释放不遵循传统机制。