[组蛋白H5对白血病细胞RNA合成及体外翻译过程的影响]

[Effect of histone H5 on RNA synthesis in leukemic cells and on the translation process in vitro].

作者信息

Smirnova I A, Chernaia Zh A, Kishinskaia E G

出版信息

Biokhimiia. 1984 Jan;49(1):136-41.

Abstract

The effects of the erythrocyte-specific histone H5 from chicken erythrocytes on HnRNA synthesis in splenocytes of Rauscher virus-infected mice were studied. It was shown that histone H5 represses the synthesis of 35S RNA typical of the Rauscher virus-producing cells but does not influence the synthesis of other HnRNA fractions. The effects of H5 and other histones on the effectiveness of poly(U) translation in a cell-free system of wheat embryos were investigated. Structurally similar histones H1 and H5 exert the strongest inhibiting action on translation. It was assumed that the previously described antileukemic action of histone H5 is realized at the levels of transcription and translation.

摘要

研究了来自鸡红细胞的红细胞特异性组蛋白H5对劳氏肉瘤病毒感染小鼠脾细胞中核不均一RNA（HnRNA）合成的影响。结果表明，组蛋白H5抑制劳氏肉瘤病毒产生细胞典型的35S RNA的合成，但不影响其他HnRNA组分的合成。研究了H5和其他组蛋白对小麦胚无细胞体系中聚尿苷酸（poly(U)）翻译效率的影响。结构相似的组蛋白H1和H5对翻译具有最强的抑制作用。据推测，先前描述的组蛋白H5的抗白血病作用是在转录和翻译水平上实现的。

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