Zhavoronkova L A, Rusinova E V
Biull Eksp Biol Med. 1984 Mar;97(3):307-8.
Experiments on conscious rabbits were made to elaborate motor conditioned reflexes through pairing stimuli with electrocutaneous reinforcement applied every 30 s. Neuronal activity in the sensorimotor cortex and putamen was recorded during formation and reproduction of the conditioned reflexes before and after haloperidol injection (0.2 mg/kg i. v.). In the putamen, haloperidol increased the number of neurons exhibiting trace conditioned activity and made the intensity and duration of these processes rise. The changes seen in the sensorimotor cortex were opposite in nature. Inhibition of trace conditioned activity in the sensorimotor cortex depended mainly on the decreased amplitude of the reaction conditioned component. The role of the dopaminergic system in the interaction of the neostriatum and sensorimotor cortex and in formation and reproduction of trace conditioned activity of both the structures is discussed.
对清醒家兔进行实验，通过每30秒施加一次电皮肤强化刺激来建立运动条件反射。在注射氟哌啶醇（0.2mg/kg静脉注射）前后，记录条件反射形成和重现过程中感觉运动皮层和壳核的神经元活动。在壳核中，氟哌啶醇增加了表现出痕迹条件活动的神经元数量，并使这些过程的强度和持续时间增加。感觉运动皮层中观察到的变化性质相反。感觉运动皮层中痕迹条件活动的抑制主要取决于条件反应成分幅度的降低。讨论了多巴胺能系统在新纹状体与感觉运动皮层相互作用以及这两个结构痕迹条件活动形成和重现中的作用。
