Rabinovich M Ia, Zhavoronkova L A, Kopytova F V, Polonskaia E L, Rusinova E V
Zh Vyssh Nerv Deiat Im I P Pavlova. 1983 Mar-Apr;33(2):334-43.
The activity of neurones in the motor cortex, caudate nucleus, putamen and globus pallidus was studied during elaboration of motor conditioned reflexes to time in rabbits, treated with 1-amphetamine and haloperidol. Mechanisms of reproduction of cells trace activity in the reflex to time at the omission of trials, reacted to 1-amphetamine by increasing the intensity of reactions in the motor cortex and inactivation in putamen cells. The curve of dynamics of intensity changes of trace discharges in the course of a series of trials omissions remained unaltered only in motor cortex; in the other structures it significantly differed from the norm of intact animals. Haloperidol depressed the mechanisms of reproduction of trace reactions of the globus pallidus cells, and made them almost fully inactive in the motor cortex; the putamen neurones reacted to haloperidol by an increase of trace reactions intensity. Against the background of the animal chronic 1-amphetamine intoxication, haloperidol normalized the dynamics and intensity of trace activity. "Therapeutic" effect of haloperidol was most distinctly expressed in the motor cortex and putamen cells, less--in the caudate nucleus and was completely absent in the globus pallidus.
在对用1-苯丙胺和氟哌啶醇处理过的家兔进行运动性条件反射定时建立的过程中，研究了运动皮层、尾状核、壳核和苍白球中神经元的活动。在试验遗漏时，对时间的反射中细胞痕迹活动的再现机制，1-苯丙胺通过增加运动皮层反应强度和使壳核细胞失活做出反应。在一系列试验遗漏过程中，痕迹放电强度变化的动力学曲线仅在运动皮层保持不变；在其他结构中，它与完整动物的正常情况有显著差异。氟哌啶醇抑制了苍白球细胞痕迹反应的再现机制，并使其在运动皮层几乎完全失活；壳核神经元对氟哌啶醇的反应是痕迹反应强度增加。在动物慢性1-苯丙胺中毒的背景下，氟哌啶醇使痕迹活动的动力学和强度恢复正常。氟哌啶醇的“治疗”作用在运动皮层和壳核细胞中表现得最为明显，在尾状核中表现较弱，在苍白球中则完全没有。
