中枢作用药物对大鼠肝脏中二甲基环氧化物代谢性别差异的新生印记的抑制作用。

Inhibitory effects of centrally acting drugs on the neonatal imprinting of sex differences in the hepatic metabolism of a dimethylated epoxide in the rat.

作者信息

Finnen M J, Hassall K A

出版信息

Br J Pharmacol. 1984 Feb;81(2):283-7. doi: 10.1111/j.1476-5381.1984.tb10076.x.

DOI:10.1111/j.1476-5381.1984.tb10076.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1986895/

Abstract

The effects of the neonatal administration of reserpine, chlorpromazine, phenobarbitone and morphine on the development of sex differences in hepatic drug metabolism in the rat have been investigated. Treatment of neonatal male rats with reserpine or chlorpromazine for the first two weeks post-partum significantly inhibited the development of sex differences in drug metabolism in adult life. Similar treatment of neonatal female rats with reserpine or chlorpromazine had no effect on the development of hepatic drug metabolism in adulthood. Morphine or phenobarbitone treatment of neonatal rats of either sex had no effect on the development of sex differences in hepatic drug metabolism in adult life.

摘要

已对新生大鼠给予利血平、氯丙嗪、苯巴比妥和吗啡对其肝脏药物代谢性别差异发育的影响进行了研究。产后头两周用利血平或氯丙嗪处理新生雄性大鼠，可显著抑制成年后药物代谢性别差异的发育。对新生雌性大鼠用利血平或氯丙嗪进行类似处理，对成年后肝脏药物代谢的发育没有影响。对新生雌雄大鼠用吗啡或苯巴比妥处理，对成年后肝脏药物代谢性别差异的发育没有影响。

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