Lawrence N J, Parkinson E K, Emmerson A
Carcinogenesis. 1984 Mar;5(3):419-21. doi: 10.1093/carcin/5.3.419.
The ability of benzoyl peroxide to inhibit metabolic co-operation in rodent cell cultures may be relevant to its recently reported tumour promoting activity in mouse epidermis. We show here that non-toxic doses of this compound reduce metabolic co-operation between human epidermal keratinocytes to approximately 30% of that found in controls. The doses of benzoyl peroxide used did not affect keratinocyte morphology or their rate of attachment to the culture substratum. These results could be important as benzoyl peroxide is widely used in industry.
过氧化苯甲酰抑制啮齿动物细胞培养中代谢协作的能力，可能与其最近报道的在小鼠表皮中的促肿瘤活性有关。我们在此表明，该化合物的无毒剂量可将人表皮角质形成细胞之间的代谢协作降低至对照组的约30%。所用的过氧化苯甲酰剂量不影响角质形成细胞的形态或它们附着于培养底物的速率。由于过氧化苯甲酰在工业中广泛使用，这些结果可能具有重要意义。
