Slaga T J, Klein-Szanto A J, Triplett L L, Yotti L P, Trosko K E
Science. 1981 Aug 28;213(4511):1023-5. doi: 10.1126/science.6791284.
Benzoyl peroxide, a widely used free radical-generating compound, promoted both papillomas and carcinomas when it was topically applied to mice after 7,12-dimethylbenz[a]anthracene initiation. Benzoyl peroxide was inactive on the skin as a complete carcinogen or as a tumor initiator. A single topical application of benzoyl peroxide produced a marked epidermal hyperplasia and induced a large number of dark basal keratinocytes, effects similar to those produced by the potent tumor promoter 12-O-tetradecanoyl phorbol-13-acetate. Benzoyl peroxide, like other known tumor promoters, also inhibited metabolic cooperation (intercellular communication) in Chinese hamster cells. In view of these results caution should be recommended in the use of this and other free radical-generating compounds.
过氧化苯甲酰是一种广泛使用的自由基生成化合物，在7,12-二甲基苯并[a]蒽引发后局部应用于小鼠时，可促进乳头状瘤和癌的发生。过氧化苯甲酰作为一种完全致癌物或肿瘤引发剂在皮肤上无活性。单次局部应用过氧化苯甲酰可导致明显的表皮增生，并诱导大量深色基底角质形成细胞，其作用类似于强效肿瘤促进剂12-O-十四酰佛波醇-13-乙酸酯所产生的作用。与其他已知的肿瘤促进剂一样，过氧化苯甲酰也抑制中国仓鼠细胞中的代谢协同作用（细胞间通讯）。鉴于这些结果，建议在使用这种和其他自由基生成化合物时应谨慎。
