Reyes E, Lisansky J
Clin Pharmacol Ther. 1984 Apr;35(4):531-4. doi: 10.1038/clpt.1984.72.
The eight subjects in this study were diagnosed as having primary or secondary depression and were treated with amitriptyline, 100 to 300 mg/day. Activity of platelet monoamine oxidase (MAO), an enzyme responsible for the degradation of biogenic amines, was determined before and after treatment with amitriptyline. Pretreatment values for MAO activity ranged from 17.94 to 44.89 U. After amitriptyline the values ranged from 0.66 to 41.94 U, a mean decrease of 50.2%. These results are consistent with the hypothesis that the tricyclic antidepressants act, at least in part, by inhibition of MAO.
本研究中的8名受试者被诊断为患有原发性或继发性抑郁症，并接受了阿米替林治疗，剂量为每日100至300毫克。血小板单胺氧化酶（MAO）是一种负责生物胺降解的酶，在使用阿米替林治疗前后对其活性进行了测定。MAO活性的治疗前值范围为17.94至44.89单位。使用阿米替林后，该值范围为0.66至41.94单位，平均下降了50.2%。这些结果与三环类抗抑郁药至少部分通过抑制MAO起作用的假设一致。
