Santinga J T, Kirsh M, Fekety R
Chest. 1984 Apr;85(4):471-5. doi: 10.1378/chest.85.4.471.
We review factors affecting survival of 44 episodes of prosthetic valve endocarditis occurring in 39 patients from 1965 to 1982. The mortality was 31.8 percent (14/44), and 21.6 percent (8/37) if the fungal cases are excluded. The development of a new murmur of valvular regurgitation in 18 patients led to valve replacement or death in every patient. Streptococcal endocarditis in 11 patients resulted in no deaths and only two valve replacements; staphylococcal infections had a mortality of 27.1 percent (6/22). Length of medical therapy before valve replacement did not relate to a successful outcome. Eight cases of early staphylococcal endocarditis occurred in which the organism was susceptible to the prophylactic antibiotic therapy. Changes in prophylaxis have led to no cases of early endocarditis over the past three years in 261 valve replacements.
我们回顾了1965年至1982年间39例患者发生的44例人工瓣膜心内膜炎发作的影响生存因素。死亡率为31.8%（14/44），排除真菌病例后为21.6%（8/37）。18例患者出现新的瓣膜反流杂音，导致每位患者均进行了瓣膜置换或死亡。11例链球菌性心内膜炎患者无死亡，仅2例进行了瓣膜置换；葡萄球菌感染的死亡率为27.1%（6/22）。瓣膜置换前的药物治疗时长与成功结局无关。发生了8例早期葡萄球菌性心内膜炎，病原体对预防性抗生素治疗敏感。预防措施的改变使得在过去三年的261例瓣膜置换中未出现早期心内膜炎病例。
