绵羊胎盘对125I-精氨酸加压素的通透性。

Permeability of the sheep placenta to 125I-arginine vasopressin.

作者信息

Stegner H, Leake R D, Palmer S M, Fisher D A

出版信息

Dev Pharmacol Ther. 1984;7(2):140-4. doi: 10.1159/000457154.

Abstract

We studied the permeability of the ovine placenta to AVP. 125I-AVP (9.3 +/- 1.9 mU) with approximately 82 (+/- 17.3) X 10(6) counts per 5 min were infused intravenously in 6 pregnant ewes. Six blood samples were collected at 10-min intervals over a 1-hour period from chronically catheterized maternal and fetal sheep. 125I-AVP in maternal and fetal plasma samples (1 ml each) were counted in a gammacounter for 5 min. Maternal counts decreased from 9,300 to 2,500 counts per 5 min over the hour following infusion but no increase in radioactivity could be measured in fetal blood, indicating that the sheep placenta is impermeable to 125I-AVP.

摘要

我们研究了绵羊胎盘对血管加压素（AVP）的通透性。向6只怀孕母羊静脉注射125I - AVP（9.3±1.9 mU），每5分钟约有82（±17.3）×10⁶计数。在1小时内，每隔10分钟从长期插管的母羊和胎羊采集6份血样。对母羊和胎羊血浆样本（各1 ml）中的125I - AVP在γ计数器中计数5分钟。输注后1小时内，母羊的计数从每5分钟9300次降至2500次，但在胎血中未检测到放射性增加，表明绵羊胎盘对125I - AVP不透性。