Kunath U, Fischer P
Dtsch Med Wochenschr. 1984 Mar 23;109(12):450-3. doi: 10.1055/s-2008-1069212.
Fifty-four patients with carcinoma of the oesophagus and cardia were selected to have either a two-cavity radical operation or blunt oesophagectomy without thoracotomy. Squamous-cell carcinomas were randomized for postoperative radiotherapy or none. Neither the two-cavity radical operation nor additional radiotherapy prolonged life expectancy. The results cast doubt on the effectiveness of local radical or curative surgery for carcinoma of the oesophagus and cardia. The only objective in the choice of treatment must be to decrease operative mortality and to make the course of the disease tolerable to the patient.
选取了54例食管癌和贲门癌患者,分别进行双腔根治手术或非开胸钝性食管切除术。鳞状细胞癌患者被随机分为术后放疗组或不放疗组。双腔根治手术和额外放疗均未延长预期寿命。这些结果使人对食管癌和贲门癌局部根治性或治愈性手术的有效性产生怀疑。治疗选择的唯一目标必须是降低手术死亡率,并使患者能够耐受疾病进程。