McCaughran J A, Edwards E, Schechter N
Epilepsia. 1984 Apr;25(2):250-8. doi: 10.1111/j.1528-1157.1984.tb04184.x.
The effects of hyperthermia-induced convulsions (HCs) on nicotinic and muscarinic receptor sites, choline acetyltransferase (ChAT), and acetylcholinesterase (AChE) in the rat were investigated. A series of 10 convulsions, evoked between 5 and 16 days of age, had marked effects on the development of the cholinergic system in the cerebellum and frontal cortex, but not in the hippocampus or hypothalamus. The concentration of muscarinic receptor sites in the cerebellum of the HC group was similar to that in controls at 2 days, greater than in controls at 8 days, but less than in controls at 55 days after the last convulsion. ChAT and AChE activities were increased at 2 days, similar at 8 days, and less than those in controls at 55 days. A decrease in muscarinic receptors and a decline in ChAT activity in the frontal cortex of the HC group were observed at 55 days after the last convulsion. The concentration of nicotinic receptor sites did not distinguish HC from control groups. A simple relationship between the experimental febrile convulsion and the cholinergic system was not found. The greatest effects were noted at 55 days after the last HC, which suggests that these may reflect secondary and possibly transsynaptic influences of the convulsion on cholinergic activity.
研究了热诱导惊厥（HCs）对大鼠烟碱样和毒蕈碱样受体位点、胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）的影响。在5至16日龄之间诱发的一系列10次惊厥对小脑和额叶皮质胆碱能系统的发育有显著影响，但对海马体或下丘脑无影响。在最后一次惊厥后2天，HC组小脑中毒蕈碱样受体位点的浓度与对照组相似，8天时高于对照组，但55天时低于对照组。ChAT和AChE活性在2天时增加，8天时相似，55天时低于对照组。在最后一次惊厥后55天，观察到HC组额叶皮质中毒蕈碱样受体减少，ChAT活性下降。烟碱样受体位点的浓度在HC组和对照组之间没有差异。未发现实验性热性惊厥与胆碱能系统之间存在简单关系。在最后一次HC后55天观察到最大影响，这表明这些可能反映了惊厥对胆碱能活性的继发性及可能的跨突触影响。
